Episode 13. Biologics and Small Molecules in IBD with Dr Darcy Holt
DARCY HOLT - BIOLOGICS AND SMALL MOLECULES FOR INFLAMMATORY BOWEL DISEASE Biologic agents (produced in living organisms or containing components of living organisms) coupled with a variety of new small molecules (acting in novel ways to influence the human immune system) have dramatically improved medical management of inflammatory bowel disease.
Biologic agents (produced in living organisms or containing components of living organisms) coupled with a variety of new small molecules (acting in novel ways to influence the human immune system) have dramatically improved medical management of inflammatory bowel disease. In this podcast episode, we are joined by Dr Darcy Holt, a senior gastroenterologist at Monash Health, with a special interest in inflammatory bowel disease and body composition to discuss -
· TNF inhibitors including the chimeric infliximab, fully humanised recombinant adalimumab, fully humanised monoclonal antibody golimumab
· Anti-integrins which regulate lymphocyte trafficking to the gut including the gut selective vedolizumab
· Interleukin inhibitors including ustekinumab which inhibits interleukin 12 and 23 as well as
· JAK inhibitors which decrease signalling by cytokines growth factor receptors including Tofacitinib
Darcy covers appropriate indications, screening for tuberculosis and viral hepatitides before therapy commencement, relative contraindications and the use of biosimilars. I found this a very interesting discussion on a group of therapies that have brought significant improvement to the quality of life of many patients with inflammatory bowel disease.
The useful references include:
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.