Episode 29. Personalised Medicine with Dr Sem Liew
Personalised medicine also known as precision medicine uses the knowledge of genetics to help predict disease development and to influence decisions about lifestyle choices and to tailor treatment to a particular individual's tumour. The hope is that personalised medicine will allow more appropriate choices of targeted therapy and minimise side effects rather than choosing a "one size fits all" approach to prescription medication.
Personalised medicine also known as precision medicine uses the knowledge of genetics to help predict disease development and to influence decisions about lifestyle choices and to tailor treatment to a particular individual’s tumour. The hope is that personalised medicine will allow more appropriate choices of targeted therapy and minimise side effects rather than choosing a “one size fits all” approach to prescription medication. Pharmacogenetics may now be used in some circumstances to minimise the likelihood for adverse reactions to a medicine and improve outcomes. To discuss this interesting subject as it applies to oncology, we are joined by Dr Sem Liew an oncologist who has already joined us to discuss immunotherapy in a previous episode. Sem will cover:
· An outline of personalised medicine
· Clinical applications
Please join me on this interesting podcast with Sem.
Useful references include:
- www.victorianoncologycare.com.au
- www.england.nhs.uk
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 28. Immunotherapy with Dr Sem Liew
Cancer is responsible for over 40,000 deaths annually in Australia and has traditionally been managed by modalities including surgery, radiotherapy and chemotherapy. In 1992, Tasuku Honjo's discovery of checkpoint proteins on tumour cells led to the birth of immunotherapy which has revolutionised the treatment of many cancers including bladder and kidney cancer, head and neck cancer, melanoma, non-small cell lung cancer and Hodgkin's lymphoma.
Cancer is responsible for over 40,000 deaths annually in Australia and has traditionally been managed by modalities including surgery, radiotherapy and chemotherapy. In 1992, Tasuku Honjo’s discovery of checkpoint proteins on tumour cells led to the birth of immunotherapy which has revolutionised the treatment of many cancers including bladder and kidney cancer, head and neck cancer, melanoma, non-small cell lung cancer and Hodgkin’s lymphoma. To broaden our appreciation of checkpoint inhibition chemotherapy in practice we are joined by expert oncologist Dr Sem Liew who discusses:
· Immunotherapy broadly
· Application
· Possible future developments
Please join me on this very interesting interview with Dr Sem Liew.
Useful references include:
- www.victorianoncologycare.com.au
- www.racgp.org .au
- www.ncbi.nlm.nih.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 27. Robotic Knee Surgery with Mr Andrew Tang
In this podcast episode we have a conversation with Mr Andrew Tang, Director of the Epworth Musculoskeletal Clinical Institute and an experienced orthopaedic surgeon operating at Epworth Richmond and St John of God Berwick since the early 1990's.
In this podcast episode we have a conversation with Mr Andrew Tang, Director of the Epworth Musculoskeletal Clinical Institute and an experienced orthopaedic surgeon operating at Epworth Richmond and St John of God Berwick since the early 1990’s. He has a particular interest in robotic knee surgery which allows improved accuracy with implant positioning and as the convenor of the Internal Orthopaedic Audit at Epworth Health he is in an excellent situation to review approaches to hip surgery, including the increasingly popular anterior approach. The ratio of knee to hip surgery currently being conducted in Australia is nearly 2:1 and it is estimated that by 2030 there will be up to 161,000 total knee replacements and 79,000 total hip replacements. Undoubtedly this figure will be contributed to by our aging population and relative obesity epidemic. Please join me in this excellent conversation with Andrew Tang as he reviews:
· Robotic knee surgery
· Surgical approaches to hip surgery
Useful references are:
pubmed.ncbi.nlm.nih.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 26. Pancreatic Cysts with Dr Mithra Sritharan
As clinicians we are often faced with the dilemma of working up cystic structures in the pancreas. These may have been discovered incidentally but may also be clinically relevant and contributing to symptoms. In this podcast episode we are joined by Mithra Sritharan a hepatopancreaticobiliary and general surgeon with a particular interest in liver and pancreatic disease, but whose management skills and high level of competence is evident from this interview.
As clinicians we are often faced with the dilemma of working up cystic structures in the pancreas. These may have been discovered incidentally but may also be clinically relevant and contributing to symptoms. In this podcast episode we are joined by Mithra Sritharan a hepatopancreaticobiliary and general surgeon with a particular interest in liver and pancreatic disease, but whose management skills and high level of competence is evident from this interview.
As clinicians we are often faced with the dilemma of working up cystic structures in the pancreas. These may have been discovered incidentally but may also be clinically relevant and contributing to symptoms. In this podcast episode we are joined by Mithra Sritharan a hepatopancreaticobiliary and general surgeon with a particular interest in liver and pancreatic disease, but whose management skills and high level of competence is evident from this interview. Today Mithra shares his knowledge in discussing:
· Pseudocysts
· Pancreatic cystic neoplasms including serous cystadenomas
· Mucinous cystic neoplasms
· Intraductal papillary mucinous neoplasms (branch duct, main duct and mixed type)
· Cystic tumours
· Non-neoplastic cysts
We cover a lot in this conversation including the Fukuoka guidelines and other investigative approaches we can draw upon to interrogate cystic structures further. Please welcome and enjoy the conversation with Mithra Sritharan.
Useful references include:
- www.caseysurgicalgroup.com.au
- www.ncbi.nlm.nih.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 25. SOL's Liver with Dr Mithra Sritharan
Our approach to space-occupying lesions (SOL's) in the liver is dependent on a firm knowledge of the potential pathology, the choice of imaging modality and the understanding of any background clinical liver disease in the index patient.
Our approach to space-occupying lesions (SOL’s) in the liver is dependent on a firm knowledge of the potential pathology, the choice of imaging modality and the understanding of any background clinical liver disease in the index patient. We are joined today by expert hepatopancreaticobiliary and general surgeon Mr Mithra Sritharan, who carefully guides us through a logical approach to liver SOL’s including:
· Cysts
· Haemangiomas
· Focal nodular hyperplasia
· Adenomas
· Malignancies
This is an excellent and clear discussion by Mithra and I am very pleased to invite you to the conversation.
Useful references include:
- www.caseysurgicalgroup.com.au
- www.ncbi.nlm.nih.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 24. Palliative Care with Dr Sally McDonald
In this episode, we talk with experienced general practitioner Dr Sally McDonald who has committed a large part of her time, energy and emotion providing palliative care for her local community.
In this episode, we talk with experienced general practitioner Dr Sally McDonald who has committed a large part of her time, energy and emotion providing palliative care for her local community. Palliative care is care focused on improving the quality of life for people and families with serious illnesses, directed at treating the symptoms of the patient, support for patient’s families and loved ones and aligning care with patient’s preferences, values and goals. Professor Ian Maddocks, a palliative care specialist, said “sometimes I think it’s better to step back and say you don’t need all that procedural stuff, what you need is good care now. You are going to die, let’s do it well.”
Along this theme Sally discusses:
· How she approaches palliative care from the perspective of the patient and family
· Treatment choices
· Services that can provide support
I am most grateful to Sally for her conversation with us. Please join this interesting episode.
Useful references include:
- lakesidesquaremedical.com.au
- Palliative Care Victoria
- www.aph.gov.au
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 23. Epilepsy with Dr Doug Crompton
Seizures may be defined as a transient disturbance of cerebral function due to abnormal paroxysmal neuronal discharge in the brain with epilepsy defined by any disorder characterised by recurrent (more than two) unprovoked seizures. It is estimated that 1-2% of the Australian population experience epileptic seizures in adult life and up to 4% of children experience epileptic seizures
Seizures may be defined as a transient disturbance of cerebral function due to abnormal paroxysmal neuronal discharge in the brain with epilepsy defined by any disorder characterised by recurrent (more than two) unprovoked seizures. It is estimated that 1-2% of the Australian population experience epileptic seizures in adult life and up to 4% of children experience epileptic seizures. With over 40 different types of epilepsy and epileptic syndromes the risks of death from this very important clinical problem is two to three times the average. It is estimated that 60-70% of patients with good epileptic care will be seizure free with treatment and this may lead to treatment withdrawal in up to 60% of adults after two to five years of successful therapy.
With this background we had a very interesting conversation with Dr Doug Crompton head of Neurology at Northern Hospital Melbourne in regard to:
· Definition of seizure and epilepsy
· Types of epilepsy
· Investigation and work up
· Management, including advice with respect to driving and daily activities
This was a very enjoyable conversation from a master in his field. Please join me with Doug.
Useful references include:
- How to treat 2016 yearbook Epilepsy Part I & II, pp. 143-154
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Special Episode 1. COVID-19 Vaccinations with Professor Gabriel Barbash
Australia is in the dawn of its vaccination program against SARS-COV2, inoculations commenced this week among frontline health workers and aged care residents as well as our Prime Minister. By comparison, Israel’s vaccination rollout has been the fastest in the world, half the population has received one dose already and one third has received both inoculations.
Australia is in the dawn of its vaccination program against SARS-COV2, inoculations commenced this week among frontline health workers and aged care residents as well as our Prime Minister. By comparison, Israel’s vaccination rollout has been the fastest in the world, half the population has received one dose already and one third has received both inoculations.
In a sense, Israel has become a real-time global experiment watched by health authorities and governments across the locked down world as Israel opens itself up again to those vaccinated. Australia has much to learn from their experience. In this special episode we are joined by Professor Gabriel Barbash from Israel, Professor of Epidemiology and Preventive Medicine in the Sackler School of Medicine, Tel Aviv University and at the forefront of Israel’s inoculation program who discusses :
•Vaccine choices
•Vaccine safety and efficacy
•Mutant strains - their impact
•Special cases to consider - the immunosuppressed patient, those with previous allergies, Guillain Barre, •Pregnant and breastfeeding women
•Herd immunity
•Children and vaccination
This was a fascinating conversation and I was deeply honoured to have Professor Barbash join us with many key points covered. Please enjoy.
References
www.nejm.org/covid-vaccine/faq
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 22. Stroke with Dr Doug Crompton
It is estimated that more than 56,000 strokes will be experienced by Australians this year (new and recurrent) and that half of Australians are living with the effects of a stroke which remains the third leading cause of death in Australia and kills more women than breast cancer and more men than prostate cancer. As more than 80% of strokes may be prevented and four in 10 stroke survivors have a recurrent stroke within a decade it is very important we understand the aetiology of strokes and how we may intervene effectively to reduce incidence and morbidity.
It is estimated that more than 56,000 strokes will be experienced by Australians this year (new and recurrent) and that half of Australians are living with the effects of a stroke which remains the third leading cause of death in Australia and kills more women than breast cancer and more men than prostate cancer. As more than 80% of strokes may be prevented and four in 10 stroke survivors have a recurrent stroke within a decade it is very important we understand the aetiology of strokes and how we may intervene effectively to reduce incidence and morbidity.
In this episode we have a conversation with Dr Doug Crompton head of neurology at Northern Hospital who discusses:
· Aetiology of CVA
· Diagnosis
· Importance of thrombolytic therapy
· Place for clot retrieval
· Primary and secondary prevention
This was a very interesting conversation with Doug, covering this fascinating topic and I am certain you will find the conversation extremely valuable.
Useful references include:
- strokefoundation.org.au
- pubmed.ncbi.nlm.nih.gov/Epidemiology: Advancing our understanding of disease
- pubmed.nbo.Ovbiagele.et.al.2011
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 21. IDDM with Dr Chin Tan
It is estimated that 130,000 Australians have been diagnosed with insulin dependent diabetes mellitus with about seven new cases per day. Approximately 60% of the diagnoses are in children and young adults under the age of 25 years. As IDDM is an autoimmune disease resulting in the destruction of insulin producing cells, glycaemic control is obtained through the administration of insulin. There have been several recent advances in continuous glucose monitoring and insulin delivery to review.
It is estimated that 130,000 Australians have been diagnosed with insulin dependent diabetes mellitus with about seven new cases per day. Approximately 60% of the diagnoses are in children and young adults under the age of 25 years. As IDDM is an autoimmune disease resulting in the destruction of insulin producing cells, glycaemic control is obtained through the administration of insulin. There have been several recent advances in continuous glucose monitoring and insulin delivery to review.
In this podcast episode we are joined by experienced endocrinologist Dr Chin Tan who will discuss:
· The importance of glycaemic control
· The choice of insulin
· Continuous glucose monitoring (CGM)
· Insulin pumps
I really enjoyed this conversation with Chin conducting it in his medical rooms and I was able to carefully inspect the latest gadgets that are available for IDDM patients. I am very pleased to bring this conversation to you.
Useful references include:
- southeasternendocrine.com
- www.ncbi.nlm.nih.gov
- www.aihw.gov.au
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 20. Endoanal ultrasound and anorectal physiology with Dr TC Nguyen
Endorectal ultrasonography combined with anorectal physiology allows the evaluation of the constituents of the wall of the anal canal and the scientific understanding of anorectal pathophysiology. It is very important to appreciate a patient's anorectal dynamics before initiating an effective management strategy for what may be a wide variety of pelvic-anorectal disorders.
Endorectal ultrasonography combined with anorectal physiology allows the evaluation of the constituents of the wall of the anal canal and the scientific understanding of anorectal pathophysiology. It is very important to appreciate a patient’s anorectal dynamics before initiating an effective management strategy for what may be a wide variety of pelvic-anorectal disorders.
In this episode we are joined by expert colorectal surgeon Mr T C Nguyen as he discusses the application of endorectal ultrasound and anorectal physiology studies –
· The management of faecal incontinence
· Management of obstructed defecation (Anismus) and dyssynergia
These medical problems are more common than is recognised and often not openly discussed by patients. Please join this interesting and helpful conversation.
Useful references include –
pubmed.ncbi.nlm.nig.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 19. Robotic Surgery with Dr TC Nguyen
Robotic assisted surgery allows doctors to perform complex procedures with more precision, flexibility and control than is possible with conventional techniques. Now used in many forms of surgery including cardiac, prostatic and orthopaedic, in this episode we are joined by the dynamic and highly skilled Mr T C Nguyen who discusses
Robotic assisted surgery allows doctors to perform complex procedures with more precision, flexibility and control than is possible with conventional techniques. Now used in many forms of surgery including cardiac, prostatic and orthopaedic, in this episode we are joined by the dynamic and highly skilled Mr T C Nguyen who discusses –
· The application of robotic surgery to colorectal pathology
· Appropriate patient selection
· Outcomes and advantages
TC shares his personal journey from a young boy fleeing war torn Vietnam making his home in Melbourne, to highly skilled and respected surgeon in this excellent conversation which I am delighted to share with you.
Useful references include –
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 18. Voluntary Assisted Dying (VAD) with Dr Frank Hofmann
Wednesday 19th June 2019 was a historic day for Victoria after parliament introduced voluntary assisted dying legislation to the community for patients facing imminent death as a result of incurable disease, with that ruling a patient’s decision to end his or her life voluntarily became a possibility.
The legislation is complicated and coupled with many safeguards. VAD has understandably been debated with great emotion and considerable controversy before and since the legislation was introduced.
In this episode we discuss the legislation with Dr Frank Hofmann who approaches the subject with extreme sensitivity, consideration and empathy including -
· Implementation of the legislation
· Safeguards, rules and checks involved
· The supports including palliative care that are available for patients choosing VAD
I think you will agree that Frank navigates the conversation with great professionalism. I am very pleased to share the episode with you.
Useful references include –
www.bettersafercare.vic.gov.au(Voluntary Assisted Dying Review Board)
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 17. CBD with Dr Sud Agarwal
Medical cannabinoids are derived from the cannabis sativa plant. There are 144 known cannabinoids, THC is perhaps the best known for its psycho-active effects, however cannabidiol (CBD) is now being recognised for its many medical applications.
Medical cannabinoids are derived from the cannabis sativa plant. There are 144 known cannabinoids, THC is perhaps the best known for its psycho-active effects, however cannabidiol (CBD) is now being recognised for its many medical applications. To discuss the role of cannabidiol in medicine we are joined by Dr Sud Agarwal, anaesthetist and CEO of one of Australia’s most interesting and emerging biotechs called Cannvalate. In this episode, Sud discusses the uses of CBD -
· as an anticonvulsant and neuroprotective agent
· as an anti-inflammatory and
· as an immunomodulator
Sud also takes us on his journey to becoming seriously involved in the biotech industry. Please enjoy this episode with the very colourful and energetic Dr Sud Agarwal.
Useful references include –
www.cannvalate.com.au
www.compassclinics.com.au
www.ncbi.nlm.nih.gov
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 16. Trauma Courses with Dr Tom Edgley
In 2019 experienced anaesthetist Dr Tom Edgley was left to defend his two properties in the rural and bushy enclave of Tonimbuk from the disastrous fires claiming over 26 properties in the region. Not only did Tom survive protecting his properties from the fire, but he also lent a major hand to his neighbours and was involved in the emotional rehabilitation of his community.
In 2019 experienced anaesthetist Dr Tom Edgley was left to defend his two properties in the rural and bushy enclave of Tonimbuk from the disastrous fires claiming over 26 properties in the region. Not only did Tom survive protecting his properties from the fire, but he also lent a major hand to his neighbours and was involved in the emotional rehabilitation of his community. He cited his attendance at emergency courses including –
· EMST (Early Management of Severe Trauma)
· Wilderness Medicine Utah
Both important resources in laying the foundation for him to follow effective strategies in the emergency
Tom has been an active advocate for extending one’s medical knowledge beyond the clinical environment of hospitals and discusses his experience, these courses and his life philosophy.
Please enjoy the conversation in this episode with Dr Tom Edgley.
Useful references include –
wmutah.org
www.surgeons.org(EMST)
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 15. Type 2 Diabetes with Dr Chin Tan
In this episode we have a conversation about Type 2 diabetes, a condition that affects at least 1.2 million Australians (5% of Australians) and for which there are a complex number of pharmacologic treatment strategies available.
In this episode, we have a conversation about Type 2 diabetes, a condition that affects at least 1.2 million Australians (5% of Australians) and for which there are a complex number of pharmacologic treatment strategies available.
We are joined by experienced and very popular Endocrinologist Dr Chin Tan who discusses –
· Oral hypoglycaemic agents that are available to us in Australia
· How to combine these agents for effective glycaemic control
· The place of insulin in type 2 diabetes
Chin also discusses the broader metabolic syndrome and the key requirement for BMI control in type 2 diabetic patients.
This is a detailed conversation which I hope you will find very informative.
Useful references include –
www.southeastendocrine.com
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Episode 14. Faecal Microbiota Transplant with Dr Darcy Holt
The transfer of stool from a healthy donor into the gastrointestinal tract of a recipient (FMT) at first consideration does not seem like a reasonable or scientific approach to the treatment of gastrointestinal diseases. Historically however, it has been used by communities for over 3,000 years, gaining credibility in 1958 after a paper by Eisemen in Denver who described treating pseudomembranous colitis this way.
The transfer of stool from a healthy donor into the gastrointestinal tract of a recipient (FMT) at first consideration does not seem like a reasonable or scientific approach to the treatment of gastrointestinal diseases. Historically however, it has been used by communities for over 3,000 years, gaining credibility in 1958 after a paper by Eisemen in Denver who described treating pseudomembranous colitis this way. More recently double-blind randomised control trials have demonstrated the efficacy of FMT in the treatment of severe clostridium difficile enterocolitis. To discuss this subject in more detail we are joined in a conversation with Dr Darcy Holt, senior consultant at Monash Health, who also works at the Centre for GI Health, as he leads us through –
· The indications for FMT
· Therapeutic advantages
· Practical aspects of FMT
With his typical academic flare and clarity of dialogue, please enjoy this interesting conversation with Darcy.
Useful references include –
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Episode 13. Biologics and Small Molecules in IBD with Dr Darcy Holt
DARCY HOLT - BIOLOGICS AND SMALL MOLECULES FOR INFLAMMATORY BOWEL DISEASE Biologic agents (produced in living organisms or containing components of living organisms) coupled with a variety of new small molecules (acting in novel ways to influence the human immune system) have dramatically improved medical management of inflammatory bowel disease.
DARCY HOLT - BIOLOGICS AND SMALL MOLECULES FOR INFLAMMATORY BOWEL DISEASE Biologic agents (produced in living organisms or containing components of living organisms) coupled with a variety of new small molecules (acting in novel ways to influence the human immune system) have dramatically improved medical management of inflammatory bowel disease.
Biologic agents (produced in living organisms or containing components of living organisms) coupled with a variety of new small molecules (acting in novel ways to influence the human immune system) have dramatically improved medical management of inflammatory bowel disease. In this podcast episode, we are joined by Dr Darcy Holt, a senior gastroenterologist at Monash Health, with a special interest in inflammatory bowel disease and body composition to discuss -
· TNF inhibitors including the chimeric infliximab, fully humanised recombinant adalimumab, fully humanised monoclonal antibody golimumab
· Anti-integrins which regulate lymphocyte trafficking to the gut including the gut selective vedolizumab
· Interleukin inhibitors including ustekinumab which inhibits interleukin 12 and 23 as well as
· JAK inhibitors which decrease signalling by cytokines growth factor receptors including Tofacitinib
Darcy covers appropriate indications, screening for tuberculosis and viral hepatitides before therapy commencement, relative contraindications and the use of biosimilars. I found this a very interesting discussion on a group of therapies that have brought significant improvement to the quality of life of many patients with inflammatory bowel disease.
The useful references include:
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 12. IBD with Dr Catherine Sorrell
Inflammatory Bowel Disease (IBD) affects approximately 85,000 Australians and 5 million people worldwide and includes Crohn's disease and ulcerative colitis. These conditions may have a major impact on patient's quality of life.
Inflammatory Bowel Disease (IBD) affects approximately 85,000 Australians and 5 million people worldwide and includes Crohn’s disease and ulcerative colitis. These conditions may have a major impact on patient’s quality of life. To discuss both ulcerative colitis and Crohn’s disease in more detail we are joined by Dr Catherine Sorrell, a very experienced and popular gastroenterologist who takes us on a fascinating journey including –
· Top down and bottom up approaches to pharmacological management
· Sharing her approach to selecting medical therapy for patients with IBD.
Catherine explains these clinical problems with great mastery. I am pleased to invite you to this conversation.
Usual references include:
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.
Episode 11. Spinal Cord Stimulation with Dr Paul Verrils
Australia has led the world in pain management, interventional techniques and pain research including in the management of severe and debilitating axial and musculoskeletal pain via spinal cord and DRG stimulation as well as in several evolving techniques for the management of visceral pain.
Australia has led the world in pain management, interventional techniques and pain research including in the management of severe and debilitating axial and musculoskeletal pain via spinal cord and DRG stimulation as well as in several evolving techniques for the management of visceral pain.
Recently potential breakthroughs have been emerging in the application of spinal cord stimulation to control symptoms related to IBS and gastroparesis. Dr Paul Verrills entered pain management as a consultant during the dawn of the speciality and has been at the vanguard of pain management both in Australia and worldwide. He established the Metro Pain Group in Clayton which has stood like a beacon and shining example of how to manage chronic pain syndromes and Paul has personally been involved in education and mentoring both in this state, in Australia and internationally. We are honoured to welcome him as our guest to this podcast where he discusses:
· Pain management techniques including spinal cord and DRG stimulation
· Why medications often fail (the elephant in the room)
· The emerging future of pain management as applied to a variety of clinical syndromes
It was a real pleasure to interview Paul and I welcome you to this conversation.
Useful references include:
- Chronic Abdominal Pain. An Evidence-based Comprehensive Guide to Clinical Management, Leonardo Kapural
To be a guest on the show or provide some feedback, I’d love to hear from you: manager@gihealth.com.au
Dr Luke Crantock MBBS, FRACP, is a gastroenterologist in practice for over 25 years. He is the founder of The Centre for GI Health, based in Melbourne Australia and is passionate about educating General Practitioners and patients on disease prevention and how to manage and improve their digestive health.